Anapolon (oxymetholone) is a very potent oral androgen. This compound was first made available in 1960, by the international drug firm Syntex. Since oxymetholone is quite reliable in its ability to increase red blood cell production (and effect admittedly characteristic of nearly all anabolic/androgenic steroids), it showed particular promise in treating cases of severe anemia. For this purpose it turned out to be well suited, and was popular for quite some time. But recent years have brought fourth a number of new treatments, most notably the non-steroidal hormone Epogen (erythropoietin). This item is shown to have a much more direct effect on the red blood cell count, without the side effects of a strong androgen.
Anapolon 50 is considered by many to be the most powerful steroid available, with results of this compound being extremely dramatic. A steroid novice experimenting with oxymetholone is likely to gain 20 to 30 pounds of massive bulk, and it can often be accomplished in less than 6 weeks, with only one or two tablets per day. This steroid produces a lot of trouble with water retention, so let there be little doubt that much of this gain is simply bloat. But for the user this is often little consequence, feeling bigger and stronger on Anapolon 50 than any steroid they are likely to cross. Although the smooth look that results from water retention is often not attractive, it can aid quite a bit to the level of size and strength gained. The muscle is fuller, will contract better and is provided a level of protection in the form of "lubrication" to the joints as some of this extra water is held into and around connective tissues. This will allow for more elasticity, and will hopefully decrease the chance for injury when lifting heavy. It should be noted however, that on the other hand the very rapid gain in mass might place too much stress on your connective tissues for this to compensate. The tearing of pectoral and biceps tissue is commonly associated with heavy lifting while massing up on heavy androgens. There is such a thing as gaining too fast. Pronounced estrogen trouble also puts the user at risk for developing gynecomastia. Individuals sensitive to the effects of estrogen, or looking to retain a more quality look, will therefore often add Nolvadex ® to each cycle.
It is important to note however, that this drug does not directly convert to estrogen in the body. Oxymetholone is a derivative of dihydrotestosterone, which gives it a structure that cannot be aromatized. As such, many have speculated as to what makes this hormone so troublesome in terms of estrogenic side effects. Some have suggested that it has progestational activity, similar to nandrolone, and is not actually estrogenic at all. Since the obvious side effects of both estrogens and progestins are very similar, this explanation might be a plausible one. However we do find medical studies looking at this possibility. One such tested the progestational activity of various steroids including nandrolone, norethandrolone, methandrostenolone, testosterone and oxymetholone 3. It reported no significant progestational effect inherent in oxymetholone or methandrostenolone, slight activity with testosterone and strong progestational effect inherent in nandrolone and norethandrolone. With such findings it starts to seem much more likely that oxymetholone can intrinsically activate the estrogen receptor itself, similar to but more profoundly than the estrogenic androgen meth Andriol.
Clearly if this is the case we can only combat the estrogenic side effects of oxymetholone with estrogen receptor antagonists such as Nolvadex® or Clomid®, and not with an aromatase inhibitor. The strong anti-aromatase compounds such as Cytadren and Arimidex ® would similarly prove to be totally useless with this steroid, as aromatase is uninvolved.
Anapolon 50 is also a very potent androgen. This trait tends to produce many pronounced, unwanted androgenic side effects. Oil skin, acne and body/facial hair growth can be seen very quickly with this drug. Many individuals respond with severe acne, often requiring medication to keep it under control. Some of these individuals find that Accutaine works well, which is a strong prescription drug that acts on the sebaceous glands to reduce the release of oils. Those with a predisposition for male pattern baldness may want to stay away from Anapolon completely, as this is certainly a possible side effect during therapy. And while some very adventurous female athletes do experiment with this compound, it is much too androgenic to recommend. Irreversible virilization symptoms can be the result and may occur very quickly, possibly before you have a chance to take action.